金纳多辅助治疗脑卒中后抑郁的临床研究

CLINICAL STUDY OF ASSISTANT TREATMENT WITH GINKGO BILOBA FOR POST STROKE DEPRESSION

目的观察金纳多辅助治疗脑卒中后抑郁的疗效及对神经功能恢复的影响。方法60例诊断为脑卒中后抑郁患者随机分为两组,一组予金纳多与百优解联合治疗;另一组单纯予百优解治疗。疗程12周,观察治疗前后HAMD评分和神经功能缺损程度评分的改变。结果治疗12周后,加用金纳多治疗组与非金纳多组HAMD评分分别为20.53±2.53和22.37±3.11,加用金纳多治疗组HAMD评分减分率显著高于非金纳多组(P<0.01);两组抗抑郁总有效率分别为76.7%和47.3%,存在统计学差异(P<0.05)。加用金纳多治疗组与非金纳多组的神经功能缺损评分分别为16.23±6.74和17.57±5.20,两组减分率比较无统计学差异(P>0.05);两组神经功能改善总有效率分别为83.3%和63.3%,无显著统计学差异(P>0.05)。结论金纳多对辅助治疗脑卒中后抑郁有效,对神经功能恢复的疗效有待扩大样本进一步研究。

Objective To observe the effeiency of Ginkgo biloba(Ginaton) as assistant treatment on post-stroke depression and physical improvement associated with stroke. Methods 60 depressed patients were randomly divided into two groups, one was provided with both Ginaton and fluoxetine(Prozac) while the other was designed to receive Prozac only. All patients were evaluated by Hanmilton Score and the CNS Score followed 12 weeks treatment. Results At 12 weeks the HAMD Score was 20.53±2.53 in Ginaton treated group compared with 22.37±3.11 in non-Ginaton treated group. More obvious decrease of HAMD Score was seen among Ginaton treated patients(P< 0.01). The total anti-depression efficiency of two groups were 76.7%and 47.3%respectively(P< 0.05). However, no advantage could be observed in physical impairment demonstrated by the improvement of CNS Score 16.23±6.74 in Ginaton treated group and 17.57±5.20 in non-Ginaton treated group(P >0.05). There was no significant difference in physical impairment efficiency between 83.3%in Ginaton treated group and 63.3%in non-Ginaton treated one(P >0.05). Conclusions Ginkgo biloba(Ginaton) can be assisted with traditional therapy to treat post-stroke depression and improve the anti-depression efficiency. Whereas further experiments to recruit more patients should be done to explore its effect on neurological functional recovery.