摘要
NIDDM (non insulin dependentdiabetesmellitus ,2型糖尿病)是一种由环境和遗传因素共同作用的成人常见慢性病。分子生物学的研究发现,磺脲受体基因的外显子和内含子均存在突变和多态性。目前认为,磺脲受体基因在NIDDM的病因和磺脲类药物降糖机制中起着重要的作用。下面就SUR1(sulfonylureareceptor 1,磺脲受体1)的基因多态性。
NIDDM is a common chronic disease caused by interaction between environment and inheritance. The exons and introns of SUR1 have mutations and polymorphisms though the research of molecular biology. Recent research demonstrated SUR1 gene is of great importance in the cause and mechanism of declining sugar in NIDDM. This article reviews the outcomes and development on the study of SUR1 genetic polymorphisms and relationship of NIDDM and pharmacogcnomics.
出处
《疾病控制杂志》
2005年第2期154-157,共4页
Chinese Journal of Disease Control and Prevention
