一氧化氮、醛固酮对高血压左室肥厚及左室舒张功能的影响

Effects of NO、ALD on the left ventricular hypertrophy and left ventricular diastolic function in patients with hypertension

目的:探讨一氧化氮(NO)、醛固酮(ALD)在高血压左室肥厚(LVH)形成中的作用及对左室舒张功能的影响。方法:以超声心动图检查55例原发性高血压(EH)患者和30例正常人并计算左室重量指数(LVMI),测定左室舒张功能等指标,并测定空腹血清NO、ALD水平,进行组间比较。结果:EH组与正常人相比NO水平降低、ALD 水平升高,左室舒张功能降低(P均<0.01)。EH-LVH组与EH组相比NO水平降低、ALD水平升高更明显(P< 0.01)。NO、ALD与LVMI相关系数(r)分别为-0.46和0.50(P<0.05)。NO、ALD与左室舒张指标E/A和PFR/ PAFR的,r分别为0.37、0.43、-0.42、-0.37(P<0.05)。结论:原发性高血压患者NO、ALD水平与LVMI和左室舒张功能减退呈显著相关性。

Objective:To assess the effects of nitric oxide (NO)、aldosterone (ALD) on the left ventricular hypertrophy (LVH) and left ventricular diastolic function in patients with essential hypertension (EH). Methods:Ration of left ventricular weight to body weight and left ventricular function on Doppler echocardiography in 55 EH patients and 30 normal individuals were measured. The levels of serum NO、ALD in all subjects were detected. All parameters were analyzed among three groups. Results:Compared with those in normal controls, the plasma NO levels were lower, ALD levels were higher, left ventricular diastolic functions were makedly insufficient (P<0.01 all) in group EH and EH-LVH,but they changed more significantly in EH-LVH group (P<0.01). NO was positively correlated with E/A and PFR/PAFR (r=0.37,0.43;P<0.05), negatively correlated with LVMI (r=-0.46, P<0.05). ALD was negatively correlated with E/A and PFR/PAFR(r=-0.42,-0.37;P<0.05) and positively correlated with LVMI (r=0.50,P<0.05). Conclusion: The levels of No and ALD are significantly related to LVMI and left ventricular diastolic dysfunction.