竹芪口服液对动物心血管、呼吸、神经系统的影响及急性毒性研究

Experimental Study on Nervous、Respiratory、Cardiovascular System and Acute Toxicity of the Zhuqi Oral Liquid

目的 研究竹芪口服液对动物心血管系统、呼吸系统和神经系统的影响以及急性毒性。方法 用竹芪口服液对小白鼠和家兔灌胃,记录20min内小白鼠活动次数,计算自发活动的抑制率;观察用药后家兔血压和呼吸频率的改变以及急性毒性反应,并计算LD50。结果 竹芪口服液对动物心血管系统、呼吸系统和神经系统无显著性影响,急性毒性试验LD50为127 82g/kg,表明该制剂无明显毒副作用。结论 竹芪口服液是一较安全有效的微生态和免疫功能调整制剂,可作为恶性肿瘤患者的辅佐药物。

Objective To study the acute toxicity and side effects of Zhuqi oral liquid (ZQOL) on animals.Methods Mice and rabbits were given ZQOL as a test drug while amobarbital、benzedrine、wyamin、caffeine as control drugs,respectively,for observing effects of the test drug on nervous、respiratory、cardiovascular system and acute toxicity and calculated LD 50 .Results The ZQOL has not obviously side reaction on nervous、respiratory、cardiovascular system of mouse and rabbits(P>0.05)and the LD 50 (ip) was found to be 127.82 g/kg.Conclusion The ZQOL has not obvious side reactions and can be used for the adjuvant of antineoplastics.