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基因治疗中非病毒载体的研究进展 被引量：4

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摘要 基因治疗中非病毒载体具有病毒载体无法比拟的优点,目前主要包括聚合物、微粒系统和肽介导的载体,连接配体以后可以靶向性传释基因,本文就其近年来的研究进展作一综述。
作者 黄容琴 裴元英
机构地区 复旦大学药学院药剂学教研室
出处 《国外医学（药学分册）》 2005年第2期77-81,共5页 Foreign Medical Sciences(Section of Pharmarcy)
关键词 非病毒载体 聚合物 靶向性传释
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献19

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同被引文献33

  • 1赵世巧,冯文莉.基因治疗的病毒载体研究进展[J].国外医学（临床生物化学与检验学分册）,2005,26(10):709-711. 被引量：15
  • 2张丽珺,方晓玲.聚合物纳米粒和胶束的主动靶向研究进展[J].国外医学（药学分册）,2005,32(6):399-403. 被引量：6
  • 3叶震敏,杨吉成.生物类基因治疗载体的研究新进展[J].临床肿瘤学杂志,2006,11(3):230-234. 被引量：2
  • 4Asfour B,Baba HA,Scheld HH,et al.Uniform long-term gene expression using adeno-associated virus(AAV) by ex-vivo recirculation in rat-cardiac isografts.Thorac Cardiovasc Surg,2002,50(6):347～350
  • 5Guo PX,Etickon S,AndersonD.A small viral RNA is required for in vitro packaging of bacterio-phage phi 29 DNA.Science,1987,236(4802):690～694
  • 6Guo PX.RNA Nanotechnology:Engineering,Assembly and applications in detection,gene delivery and therapy.J Nanosci Nanotrchnol,2005,5:1964～1982
  • 7Guo PX.Structure and function of φ29 hexameric RNA that drives the viral DNA packaging motor.Prog in Nucl Acid Res & Mole Biol,2002,72:415
  • 8Chen C,Sheng S,Shao Z,et al.A dimmer as a building block in assembling RNA.Journal of Biological Chemistry,2000,275(23):17510～17516
  • 9Mark A R.Affinity of molecular interactions in the bacteriophage φ29 DNA packaging motor.Nucleic Acids Research,2006,34(9):2698～2709
  • 10Kyle G,Guo PX.Mapping the inter-RNA interaction of bacterial virus Phi29 packaging RNA by site-specific photoaffinity cross-linking.J Biol Chem,2000,275:2817～2824

引证文献4

二级引证文献2

国外医学（药学分册）
2005年 第2期

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