新生儿缺氧缺血性脑病肾功能变化分析

Analysis of Changes of Renal Function in HIE of Newborns

目的 :探讨新生儿缺氧缺血性脑病 (HIE)肾功能变化情况。方法 :用生化仪对 2 6例HIE和 2 0例正常足月新生儿进行血清尿素氮、肌酐及电解质检测。结果 :发现HIE患儿发生电解质紊乱者明显高于正常足月新生儿 (χ2 =6. 879,P <0.0 1) ,中、重度HIE患儿并发肾功能障碍者 (血清尿素氮、肌酐 )明显高于轻度患儿 (χ2 =4.816 ,P <0.0 1)。结论 :在新生儿缺氧缺血性脑病治疗过程中 ,尤其对中、重度患儿 ,早期就应该积极预防、治疗影响肾功能的各种病因 ,改善肾功能 ,纠正电解质紊乱 ,防止肾衰发生 ,降低病死率。

Objective:To investigate the changes of renal function in HIE of newborns.Methods:Biochemical instruments were used to detect serum urea nitrogen,creatinine,and electrolyte in 26 HIE of newborns and 20 normal full-term newborns.Results:The results showed significantly higher electrolyte in the former((χ~2=)6.879 (P<)(0.01).)There were more HIE complicated with renal dysfunction in newborns with moderate and severe HIE than in those with mild HIE ((χ~2=)4.816 (P<)0.01).Conclusion:Active early prevention and treatment should be given to the disease,especially to moderate and severe HIE of newborns to keep from renal failure and decrease the death rate.