利尿剂在高血压治疗中的重要地位

Important Role of Diuretic in Hypertension Treatment

本文采用文献综述的方法,确定利尿剂在高血压治疗中的地位。国际临床试验结果进行荟萃分析显示,小剂量利尿剂能减少心血管病事件的发生和死亡率;大规模临床试验证明利尿剂降压效果是肯定的,尤其对老年人、肥胖及高血压合并心力衰竭的患者效果更加明显;利尿剂除了具有显著的降压作用以外,还能起到良好的协同作用,是复方降压制剂中的主要成分;在应用利尿剂的同时,要正确处理好利尿剂引起的代谢障碍。事实证明小剂量利尿剂是预防心血管病发病和死亡的有效一线药物,在高血压治疗中占重要地位。

In this paper, we reviewed results of several larger clinical trials of antihypertensive drugs to confirm the important role of diuretic in hypertension treatment. The meta-analyses of international clinical trials indicated that low-dose diuretics were associated with reduced morbidity and mortality of cardiovascular disease events. The larger-scale clinical trials affirmed the effective results of diuretic on blood pressure decreasing, especially in the elder or fat patients or with congestive heart failure. The diuretic is the major component of combination drug for its better cooperation with other antihypertensive drugs. It should be pay more attention to deal with the metabolic disorders due to diuretic. In conclusion, the low-dose diuretics play an important role in hypertension treatment as the first-line drug for prevention of the morbidity and mortality of cardiovascular diseases.