溴隐亭治疗肢端肥大症继发糖尿病与糖耐量异常报告

SECONDARY DIABETES AND IGT IN THE TREATMENT OF ACROMEGALY WITH BROMOCRIPTINE

１９８３─１９９３年６月收治肢端肥大症２８例中，糖耐量异常（ＩＧＴ）５例占１８．５％，糖尿病１１例占３９．２８％，采用溴隐亭治疗５例ＩＧＴ恢复正常，３例无临床症状，ＦＢＳ８．８～１５ｍｍｏｌ／Ｌ治疗一月后ＦＢＳ降至正常。４例有临床症状ＦＢＳ１５～１６ｍｍｏｌ／Ｌ，仅用溴隐亭７．５～１５ｍｇ／日治疗，ＦＢＳ除１例外均正常。４例ＦＢＳ１２．０４６～４９．２３７ｍｍｏｌ／Ｌ，尿糖＋＋～＋＋＋，采用饮食控制并加用胰岛素２４～９６ｕ／日，３例再加服优降糖２．５～７．５ｍｇ／日，疗效不佳，加用溴隐亭后获得较明显效果。认为肢端肥大症继发糖尿病，采用治疗Ⅰ型、Ⅱ型糖尿病的方法，均不能获得满意疗效，即使放疗后或手术加放疗后均一样，应首选溴隐亭治疗。

AbstractEleven cases of acromegaly withovert secondary diabetes were treated byBromocriptine.The IGT of 5 cases at 1 month after administration of Bromo-criptine returned to normal.the followup FBS level of 6 cases at 1 monthafter administration of Bromocriptine returned to normal from 8.8～15mmol/L before the treatment.5 cases whose FBS ranged from 12.046 to49.231 mmol/L and glucosunia from(++)to(+++)were treated with acombination of diet and Insuline with a dose 24-96U/day at begining,but nosignificant effects developed.So one among them was treated additionally withBromocriptine in dosage starting from 2.5mg and increasing gradually up to10mg per day,1 week later her FBS decreased from 12.046 mmol/L to 4.219mmol/L and glucosunia became negative.