60例海洛因依赖者外周血淋巴细胞微核发生率观察

Quantitative study of Lymphocytic Micronucleus in the peripheral blood of Heroin Addicts

本文对６０例海洛因依赖者外周血淋巴细胞微核发生率（简称微核率）进行研究观察。结果表明：吸毒并肝损伤组、吸毒无肝损伤组和非吸毒肝损伤组的微核率均明显高于健康人对照组（Ｐ＜０．０１）。吸毒并肝损伤组的微核率虽高于非吸毒肝损伤组，但均无统计学上差异，结果提示，吸毒人群微核率增高，其原因，除海洛因直接影响外，还可能与海洛因的不纯或使用过程中有肝炎病毒感染有关。

ymphocytic Micronucleus in peripheral blood of 60 cases of heroin addictswere studied quantitivly and compared with that of nonaddicts.The resultsshowed that the micronuclei rate of two groups in heroin addicts,whetherfollowed by hepatic damage or not,was significantly higher than that ofhealthy control(P<0.01),but not had distinct difference statistically fromthat off addicts with hepatic damage(P>0.05).We obtained with micronucle-us change:high rate of lymphocytic miconucleus in herion addicts populationmight result from direct effect of heroin.In addition,abuse of inpureheroin or infection of hepatic virus during drug takeing might be potential factor for the increace of micronuclei rate in heroin addicts.