摘要
应用银染技术，对２４例结肠腺瘤Ⅲ级不典型增生，３０例绒毛状腺瘤，１４例绒毛状腺瘤Ⅲ级不典型增生和２９例高分化管状腺癌，进行银染核仁形成区嗜银蛋白（Ａｇ—ＮＯＲｓ）定量研究，观察Ａｇ—ＮＯＲｓ数量、形态、大小和分布在结肠肿瘤交界性病变中的表达。结果表明：（１）高分化管状腺癌比结肠腺瘤Ⅲ级不典型增生Ａｇ—ＮＯＲｓ均数／核高，大、小型颗粒数多，两极离散度大，以细小颗粒增多明显。（２）绒毛状腺瘤Ａｇ—ＮｏＲｓ数量、形态、大小和分布的变化显著，接近高分化管状腺癌，二者Ａｇ—ＮＯＲｓ均数／核无差异，数量范围上几乎全部重叠。提示Ａｇ—ＮＯＲｓ四项指标定量研究对结肠肿瘤，特别是Ⅲ级不典型增生与绒毛状腺瘤之结肠癌前病变有较好的监测作用。
quantitative study on the morpholgy of
silver of nucleolar organizerregions(Ag─NORs in borderline colorectal lesions was
perfected.24 Ⅲ gradeatypical hyperplasia of the adenomas, 30 villious adenomas, 14 Ⅲ grade
atypicalhyperplasia of the villous adenomas and 29 well-differentiated tubular
adenocar-cinomas were investigated with this method. The number, shape, size and
dis-tribution of Ag-NORs were counted and analysed. The results showned:(1)The total number,
and number of Ag-HORs in well-differentiated tubularadenocarcinama, it was significantly higher
than that in Ⅲ grade atypicalhyperplasia of the adenoms.(2 ) The number, size and distribution
of Ag-NORs in villous adenoma were close similar to those of well-differentiated tubular
adenocaricinoma. These study suggests that the evaluation of four quan-titative perameters of
Ag-NORs in precarcinomatous lesion of the adenoma, particularly inⅢ grade atypical
hyperplasia and villous adenoma in useful inclinical practice.
出处
《云南医药》
CAS
1994年第6期402-404,共3页
Medicine and Pharmacy of Yunnan
基金
中华医学基金会
