Pachysandra型生物碱的化学结构及活性筛选

STUDY ON THE CHEMICAL STRUCTURES AND BIOACTIVE SCREENING OF PACHYSANDRA ALKALOIDS

本文简要报道黄杨科板凳果族植物中Ｐａｃｋｙｓａｎｄｒａ型生物碱的化学结构研究概况及药理活性筛选的初步结果。药理活性筛选结果表明，筛选的化合物大多具有抗癌（Ｐ３８８和Ｌ１２１０）活性，部分化合物显示较高活性的抗溃疡作用。

Most plants of Pachysandreae(Buxaceae),such as Sarcococca ruscifolia Stapf and Pachysandra axillaris Franch,have been used as medicinal herbs in Chinese folk for the treatments of stomach troubles, rheumatalgiaes,stanch bleedings, detumeseences etc..Six years ago, we began to cooperate with Japanese Yamanouchi Phaimaceutical Co., Ltd,in the antiulcer,antitumor and other bioactive sereeninig on these folk medicinal herbs. The test-ing results showed that extracts of Sarcococca ruscifolia and Pachysandra axillaris have antiulcer,antigastrits and antitumor activies ( Table 1-3).Then,we started to study on the bioactive components from Pachysandreae plants. Up to now,more than 30 steroidal alkaloids were isolated from the EtOH extracts of Pachysandra axillaris,Sarcococca. ruscifolia and S. vagans.In this paper, we wish to present the various salient features of these Pachysandra alkaloids.Furthermore,this paper briefly describes the screening results of various phamacological activity for these Pachysandra Alkaloids.The screening results displayed that most of Pachysandra alkaloids show antitumor activites,and some of them show high antiulcer activities.