同型半胱氨酸血症与2型糖尿病慢性并发症的关系

Relationship between plasma homocysteine and chronic complications in type 2 diabetes mellitus

目的探讨血浆同型半胱氨酸(Hcy)与2型糖尿病慢性并发症的关系。方法将60例2型糖尿病患者分为糖尿病组(30例)和糖尿病合并并发症组(30例),以健康者作为对照组,测定各组的空腹血糖、餐后2 h血糖、糖化血红蛋白、同型半胱氨酸,并对各组间Hcy进行统计学比较。结果糖尿病合并慢性并发症组Hcy较对照组显著升高(P<0.01)。而并发症组与糖尿病组相比亦显著升高(P<0.01)。结论高Hcy与糖尿病慢性并发症明显相关,其机制可能与血管内皮损伤有关。

Objective To assess the relationship between plasma homocysteine with chronic complications in type 2 diabetes mellitus. Method Plasma homocysteine levels, blood glucose, and HbA1c were measured in 60 diabetic patients (including 30 with and 30 without complications) and 31 normal subjects. The difference in the occurrence of chronic complications between patients with and without hyperhomocysteinemia was investigated. Results Plasma homocysteine level was significantly higher in type 2 diabetic patients with chronic complication than in normal control subjects (P<0.01), and patients with chronic complications had higher homocysteine levels than those without chronic complications (P<0.01). Conclusion Hyperhomocysteinemia is related to chronic complication in 2 diabetes mellitus, possibly due to the injury to the vascular endothelium by homocysteine.