心肌肌钙蛋白T快速检测对急性心肌梗死诊断的临床应用

Clinical application of rapid bedside cardiac troponin t assay in the diagnosis of acute myocardial infarction

目的 探讨心肌肌钙蛋白T(cTnT)快速检测对急性心肌梗死(AMI)的早期诊断和不良后果预测价值。方法 对123名高度可疑的AMI患者在发病后24小时内系列检测cTnT和肌酸激酶同工酶MB(CK MB)活性。结果 (1)在发病后6小时、12小时和24小时内cTnT检测AMI的敏感性分别为38. 8%、85. 4%和94. 2%,特异性为100%; (2)在发病后6小时和24小时内,CK MB(活性)检测AMI的敏感性分别为70%和77. 7%; (3)AMI患者随着cTnT水平升高, 30天死亡率显著增加(P<0. 01)。结论 cTnT快速检测对诊断AMI具有高度的敏感性和特异性,并能预测患者的不良后果。该方法简单快速,适宜床边检测。

Objective To find the usefulness of rapid bedside cardiac troponin T(cTnT)assay in the diagnosis and adverse outcome assessment of acute myocardial infarction(AMI).Methods cTnT and Creatine kinase MB(CK-MB) activity were detected in 123 suspicious AMI patients within 24h after onset of symptom.Results (1)The sensitivity of cTnT for AMI within 6h,12h and 24h after onset were respectively 38.8%,85.4% and 94.2%,the specificity was 100%.(2)The sensitivity of CK-MB (activity) for AMI within 6h and 24h after onset were respectively 70% and77.7%.(3)The elevation of cTnT trial noted a strong correlation with mortality at 30 days in AMI patients.Conclusion Rapid cardiac troponin T assay had a high sensitivity and specificity in diagnosis of AMI,and could prognosticate AMI.It is easy to manipulate at bedside and fast get result.