眼表粘蛋白的调节因素

Regulation of ocular surface mucin secretion

随着对泪膜的深入认识,眼表粘蛋白的重要性及其调节因素日益受到重视。眼表粘蛋白的调节可能受多种因素影响。眼表粘蛋白主要由结膜杯状细胞和角结膜上皮细胞分泌,这些细胞均受副交感神经和交感神经的支配。一些炎症介质也可以刺激粘蛋白的分泌。对粘蛋白及其调节因素的研究可能会为干眼症的治疗提供新的选择。

With the development of recognization of tear film,more attention has been paid on the ocular surface mucin and its regulation.Regulation of mucin secretion may be under the influence of multiple pathways.Conjunctival goblet cells and ocular surface epithelial cells,which are the main source of ocular surface mucin,appear to be under parasympathetic and sympathetic control.Some inflammatory mediators also can stimulate mucin secretion.The understanding of the functional roles of mucin and the regulatory steps governing its synthesis and secretion is necessary to develop effective treatment strategies for dry eye.