急性脑梗死脑磁图体感诱发磁场发生源ECD强度研究

The study of ECD strength of somatosensory evoked magnetic fields in patients with acute cerebral infarction by magnetoencephaigraphy

目的:研究急性脑梗死患者脑磁图(magnetoencephalography,MEG)体感诱发磁场发生源等价电流偶极子(equivalentcurrentdipole,ECD)强度变化特征。方法:对15例急性脑梗死患者于发病后3～4周进行体感诱发磁场(SEFS)检测;同时检测16例健康志愿者作为对照。电刺激部位为腕部正中神经处,电流脉冲宽度0.3ms,刺激间隔0.5s。SEFS波峰由ECD评估。结果:所有受检者SEFs的最基本波形为M20,急性脑梗死患者患侧ECD强度减小(P<0.01)。结论:MEG可灵敏地检测出急性脑梗死患者体感皮层中枢功能损伤。

Objective: To investigate the ECD strength of somatosensory evoked magnetic fields (SEFs) in patients with acute cerebral infarction by magnetoencephalgraphy (MEG). Methods: SEFs were recorded from 15 patients with acute cerebral infarction and 16 health volunteers with 306-channel whole-head MEG. Electric stimuli were presented with interstimulus intervals of 0. 5s. The peaks of SEFs were estimated by equivalent current dipole(ECD). Results: M20 was the most elemental components of SEFs. the strength of ECD of M2O was smaller in affected hemisphere in patients with acute cerebral infarction (P<.01). Conclusion: Latent cortical impairment can be examined by MEG with higher spatial and temporal resolution.