rhG-CSF在动员外周血造血干/祖细胞过程中对T细胞的影响及机制

Effects of rhG-CSF on T Cell during Peripheral Blood Stem/Progenitor Cell Mobilization and Its Mechanisms--Review

重组人粒细胞集落刺激因子(rhG-CSF)对人体具有广泛的免疫调节作用。在动员外周血造血干／祖细胞 过程中给予的rhG-CSF可以使外周血T淋巴细胞数量和功能发生改变,并影响移植后GVHD的发生。rhG-CSF主 要通过时单核细胞和树突状细胞的作用而间接影响T细胞,其中单核细胞分泌的大量IL-10对调节T细胞的细胞 因子分泌、增殖和细胞毒效应具有重要作用。IL-10作用于T细胞后引起的SOCS3表达显著增高可能在相关的信 号转导机制中具有重要作用。本综述重点阐述rhG-CSF在动员过程中对T细胞的影响及相关机制。

Recombinant human granulocyte-colony-stimulating factor (rhG-CSF) can widely regulate human immu-nologic response. In the protocol of peripheral blood stem/progenitor cell mobilization, rhG-CSF can change the numbers and functions of T cells. Then the results can impact the incidence of graft-versus-host disease after allogeneic peripheral blood stem/progenitor cell transplantation. The regulation of rhG-CSF on T cell is an indirect action which is based on the direct action to monocytes and dendritic cells. The numerous IL-10 secreted by monocytes plays a key role in cytokines production, proliferative response and cytotoxicity of T cells. Endogenous IL-10 can induce high expression of SOCS3 and the SOCS3 is very important for regulating the signal transduction of the activities of T cells. In this re-uiew influences of rhG-CSF on T-cells in mobilization process and related mechanisms were elaborated with emphasis.