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MT1-MMP的表达与上皮性卵巢癌生物学特性及预后关系的研究 被引量：1

Study on expression of MT1-MMP in epithelial ovarian cancer and correlation with biological characteristics and prognosis
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摘要 目的　研究膜型基质金属蛋白酶-1(membranetype-1matrixmetalloproteinase,MT1-MMP)蛋白在上皮性卵巢癌组织中的表达及意义。方法　应用免疫组化SP法检测56例上皮性卵巢癌、15例上皮性卵巢良性肿瘤及10例正常卵巢组织中MT1-MMP的表达和微血管密度(microvesseldensity,MVD)。结果　MT1-MMP在卵巢癌组织中的阳性表达率(67. 9% )显著高于卵巢良性肿瘤(4 /15)和正常卵巢组织(1 /10) (P<0. 01)。MT1-MMP的表达水平与临床分期、组织学分级、有无淋巴结转移和MVD密切相关。在单因素生存分析中,MT1-MMP的表达与患者预后不良有关。结论　MT1 -MMP在上皮性卵巢癌中的异常高表达可能在肿瘤的侵袭转移和血管生成中起重要作用,对判断预后有一定的指导意义。 Objective To study the expression and significance o f MT1-MMP protein in epithelial ovarian cancer. Methods Im munohistochemical staining (SP method) was used to detect the expression of MT1- MMP protein and MVD in 56 epithelial ovarian cancer, 15 epithelial benign tumors of ovary, and 10 normal ovary tissues. Results The expre ssion of MT1-MMP protein in epithelial ovarian cancer (67.9%) was significantly higher than those in benign ovarian tumor (4/15) and normal ovary(1/10)( P<0.01). The expression level of MT1-MMP correlated with FIGO staging , differentiation, lymph node metastasis and MVD. Expression of MT1-MMP showed a significant influence on survival in univariate analysis. Conclusion Overexpression of MT1-MMP in epithelial ovarian cancer may play an important role during tumor angiogenesis, invasion and metastasis. Moreover, it may be of value in predicting the patients' prognosis .
作者 陈沂 吴绪峰 陈惠祯
机构地区 武汉大学中南医院妇瘤科
出处 《现代肿瘤医学》 CAS 2005年第2期167-169,共3页 Journal of Modern Oncology
基金 湖北省教委资助项目(No. 2001A14006)
关键词 卵巢肿瘤 膜型基质金属蛋白酶-1 侵袭转移 预后 ovarian neoplasms membrane type-1 metallop roteinase invasion and metastasis prognosis
分类号 R737.31 [医药卫生—肿瘤]
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参考文献9

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同被引文献16

  • 1张海泉,袁先厚,江普查,文志华.MT1-MMP及MMP2在人脑胶质瘤中的表达及意义[J].现代肿瘤医学,2006,14(2):138-141. 被引量：6
  • 2Smith MF, Ricke WA, Bakke LJ, et al. Ovarian tissue remodeling: role of matrix metalloproteinase and their inhibitors. Mol Endocrinol, 2002, 191(45):45-56.
  • 3Ogiwara K, Takano N, Shinohara M, et al. Gelatinase A and membrane type matrixmetalloproteinases- 1 and -2 are responsible for follicle rupture during ovulation in the medaka. PNAS Online, 2005, 102(24):8 442-7.
  • 4Liu k, Wahlberg P, Ny T, et al. Coordinated and cell-specific regulation of membrane type matrix metalloproteinase-1 (MT1-MMP) and its substrate matrix metalloproteinase- 2(MMP-2) by physiological signals during follicular development and ovulation. Endocrinology, 2000, 139 (11):4 735-8.
  • 5Leanne J. Bakke LJ, Dow MPD, et al. Effect of the preovulatory gonadotropin surge on matrix metalloproteinase (MMP-14), MMP-2, and tissue inhibitor of metalloproteinases-2 expression within bovine periovulatory follicular and luteal tissue. Biol Reprod, 2002, 66(6): 1 627-34.
  • 6Drew AF, Blick TJ, Lafleur MA, et al. Correlation of tumor and stromal derived MT1-MMP expression with progression of human ovarian tumors in SCID mice. Gynecol Oncol, 2004, 95(3):437-48.
  • 7Dalberq K, Eriksson E, Enberq U, et al. Gelalinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer. World J Surg, 2000, 24(3): 334-40.
  • 8Lhota S, Elavathil LJ, Vukmirovi-Popovi S, et al. Immunolocalization of matrix metalloproteinases and their inhibitors in clinical specimens of bone metastasis from brest carcinoma. Clin Exp Metastasis, 2000, 18(6):463-70.
  • 9Obtani H, Tabata N, Nagura H, et al. Immunooelectron microscopic localization of gelatinase A in human gastrointestinal and skin carcinoma difference between cancer cell and fibroblasts. Jap J Cancer Res, 2005, 86(3):304-9.
  • 10Hernandez-Barrantes S, Toth M, Bernardo MM, et al. Binding of active (57 kDa) membrane type-1 matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP-2) regulates MT1-MMP processing and proMMP-2 activation. J Biol Chem, 2000, 275 (16):12 080-9.

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现代肿瘤医学
2005年 第2期

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