单药希罗达治疗晚期乳腺癌和结直肠癌疗效观察

Efficacy of single-agent Xeloda in treatment of patients with advanced breast and colrectal cancer

目的探讨希罗达单药治疗晚期乳腺癌和结直肠癌的近期疗效及不良反应.方法 21例晚期乳腺癌和结直肠癌患者均给予希罗达口服,每日2次,餐后服用,2500mg/m2·d,连续服用14d后停药7d,治疗周期为21d,至少治疗2个周期.结果本组部分缓解(PR)5例,病情稳定(SD)10例,疾病进展(PD)6例,总有效率23.8%.不良反应:手足综合征9例,色素沉着6例,恶心5例,呕吐4例,厌食6例,腹泻5例,白细胞下降6例,血小板下降2例,大多数为Ⅰ～Ⅱ度.结论希罗达治疗晚期乳腺癌和结直肠癌疗效肯定,用药方便,耐受性好,毒副反应轻.

Objective To evaluate the efficacy and sa fe ty of single-agent Xeloda in patients with advanced breast and colorectal cancer .Methos Twenty one patients were treated with oral Xelods ,2000mg/m2/d,twice daily,on days 1~14 every 21 days,At least 2 cycles were adm inistered.Results The overall response rate was 23.8%,with 5 PR,10 SD and 6 PD. In terms of adverse reaction,foot and hand syndrome co uld be seen in 9patients,skin pigmentation in 6 patients.Nausea,vomiting,anorexi a and diarrhea were observed in 5,4,6and 5 cases,6 and 2 pa- tients had mild gr anulocytopenia and thrombocytoprnnia.Concusion Xeloda is an efficacious and better-tolerated alternative treatment for the paticents with advanced breast and colorectal cancer.