摘要
目的:验证舒降之、血脂康、美百乐镇的调脂作用并做比较研究。方法:6 0例高脂血症患者随机分为3组,舒降之2 0mg每晚顿服;美百乐镇10mg每晚顿服;血脂康0 .6 g早晚各1次口服;服药前及服药后4、8、12周测定血脂。结果:舒降之组治疗后4周TC、LDL -C有下降(P <0 .0 5 ) ,12周比4周下降更明显(P <0 .0 5 )。美百乐镇组治疗后4周TC、LDL -C有下降(P <0 .0 5 ) ,12周与4周无明显变化(P >0 .0 5 )。两组的TG、HDL -C治疗前后均无明显变化(P >0 .0 5 )。血脂康组治疗后4周TC、LDL -C、TG有下降(P <0 .0 5 ) ,TC、LDL -C 12周比4周下降更明显(P <0 .0 5 ) ;HDL治疗前后无明显变化(P>0 .0 5 )。舒降之组治疗后8周、12周LDL -C分别下降( 4 0 % ,4 5 % ) ,明显大于血脂康组( 31%与36 % )和美百乐镇组( 31%与35 % ) (P <0 .0 5 )。血脂康组治疗后8周、12周TG分别下降( 33% ,35 % ) ,明显大于舒降之组( 2 5 % ,2 6 % )和美百乐镇组( 18% ,19% ) (P <0 .0 5 )。3组TC、TG、HDL -C总有效率无显著差异(P >0 .0 5 )。结论:舒降之、血脂康、美百乐镇降脂疗效确切,但3种药疗效判断及调整治疗的时间窗不同。舒降之降LDL -C能力强。
Objective:To compare the effects of simvastatin,xuezhikang and pravastatin in patients with primary hyperlipidemia.Methods:Sixty patients were randomly divided into three groups,simvastatin 20mg were taken once a day at night;provastatin 10mg were taken once a day at night;xuezhikang 0.6g were taken twice a day in the morning and at night.Blood samples were taken before and 4 weeks,8 weeks,12 weeks after the treatment.Results:In simvastatin group:the serum levels of total cholesterol(TC),low-density lipoprotein cholesterol(LDL C) decreased markedly at the end of 4 weeks compared with those of the baseline ( P <0.05).Significant differences in TC,LDL C were found between the end of 4 weeks and 12 weeks ( P <0.05).In pravastatin group:there is a noticeable drop in TC,LDL C at the end of 4 weeks,but no further obvious drop between 4 weeks and 12 weeks.Concentrations of TG and HDL C were not changed obviously in both groups after 12 weeks of treatment compared with the baseline ( P >0.05).In xuezhikang group:after 4 weeks of treatment,TC,TG,LDL C reduced markedly( P <0.05).Further significant lowering of TC,LDL C were noted after 12 weeks as compared with 4 weeks ( P <0.05).Only HDL C was not changed after the treatment in contrast with the baseline ( P >0.05).From the change rates,we can see after 8 weeks,12 weeks of treatment the level of LDL C drcreased more significantly in simvastatin group (40%,45%) than in xuezhikang (31%,36%) and provastatin (31%,35%) ( P <0.05);however,the level of TG lowered more obviously in xuezhikang group (33%,35%) than in simvastatin(25%,26%) and provastatin (18%,19%)( P <0.05).At the end of 12 weeks,the total effective rates of decreasing TC,TG,HDL C have no significance among three groups ( P >0.05).Conclusion:The clinical effects of simvastatin,xunzhikang,provastatin on primary hyperlipidemia were equal among the three groups,but the time is different about when they take great effects respectively.Next,LDL C lowering effect of simvastatin was significant.Finally,xuezhikang was the best in reducing TG among the three groups and it has a relatively good economic effectiveness.
出处
《重庆医科大学学报》
CAS
CSCD
2005年第2期278-281,284,共5页
Journal of Chongqing Medical University
关键词
高脂血症
舒降之
血脂康
美百乐镇
Hyperlipidemia
Simvastatin
Xuezhikang
Provastatin