摘要
The two enantiomers of flutriafol were resolved by means of high-performance liquid chromato-(graphy) with a cellulose derivative chiral stationary phase. The mobile phase was n-hexane, and five alkane (alcohols) were used as the polar modifier. The effects of the modifier and its concentration on the resolution were studied, and the influence of the temperature was also investigated. The results show that the separation factor could reach 1.41 at room temperature with 5%(volume fraction) isopropanol in the mobile phase. (Lower) column temperature resulted in a higher separation factor. The separation mechanism was primarily (discussed).
The two enantiomers of flutriafol were resolved by means of high-performance liquid chromato-(graphy) with a cellulose derivative chiral stationary phase. The mobile phase was n-hexane, and five alkane (alcohols) were used as the polar modifier. The effects of the modifier and its concentration on the resolution were studied, and the influence of the temperature was also investigated. The results show that the separation factor could reach 1.41 at room temperature with 5%(volume fraction) isopropanol in the mobile phase. (Lower) column temperature resulted in a higher separation factor. The separation mechanism was primarily (discussed).
出处
《应用化学》
CAS
CSCD
北大核心
2005年第4期445-447,共3页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金资助项目(20377052)
关键词
粉唑醇
对映体
分离
手性固定相
flutriafol,enantiomer,separation,chiral stationary phase