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HPLC法拆分粉唑醇对映体 被引量：6

Enantiomeric Separation of Flutriafol by HPLC
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摘要 The two enantiomers of flutriafol were resolved by means of high-performance liquid chromato-(graphy) with a cellulose derivative chiral stationary phase. The mobile phase was n-hexane, and five alkane (alcohols) were used as the polar modifier. The effects of the modifier and its concentration on the resolution were studied, and the influence of the temperature was also investigated. The results show that the separation factor could reach 1.41 at room temperature with 5%(volume fraction) isopropanol in the mobile phase. (Lower) column temperature resulted in a higher separation factor. The separation mechanism was primarily (discussed). The two enantiomers of flutriafol were resolved by means of high-performance liquid chromato-(graphy) with a cellulose derivative chiral stationary phase. The mobile phase was n-hexane, and five alkane (alcohols) were used as the polar modifier. The effects of the modifier and its concentration on the resolution were studied, and the influence of the temperature was also investigated. The results show that the separation factor could reach 1.41 at room temperature with 5%(volume fraction) isopropanol in the mobile phase. (Lower) column temperature resulted in a higher separation factor. The separation mechanism was primarily (discussed).
作者 王鹏 江树人 姜伟 周文景 王秋霞 王萍 周志强
机构地区 中国农业大学理学院应用化学系
出处 《应用化学》 CAS CSCD 北大核心 2005年第4期445-447,共3页 Chinese Journal of Applied Chemistry
基金 国家自然科学基金资助项目(20377052)
关键词 粉唑醇 对映体 分离 手性固定相 flutriafol,enantiomer,separation,chiral stationary phase
分类号 O658 [理学—分析化学]
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参考文献12

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二级参考文献3

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共引文献12

同被引文献52

  • 1冯化成.新颖杀菌剂硅氟唑(simeconazole)[J].世界农药,2004,26(3):47-48. 被引量：6
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  • 3陈磊,万谦宏.雌马醇对映体的高效液相色谱分离[J].药物分析杂志,2006,26(6):795-798. 被引量：6
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  • 7GAO Ge, WANG Qin, YU Xiao-qi, et al. Highly enantios elective synthesis of γ-hydroxy-α,β-acetylenic esters by asymmetric alkyne addition to aldehydes [ J ]. Angew. Chem. Int. Ed. ,2006,45(1) :122-125.
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引证文献6

二级引证文献28

应用化学
2005年 第4期

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