摘要
Intermediate 6-cyanoindole was obtained from 4-methylbenzonitrile as a raw material via nitration with the mixed acid, condensation with N,N-dimethylformamide dimethyl acetal and cyclic reaction with Raney nickel-hydrazine. 6-Cyanoindole-3-carboxyaldehyde was synthesized via the Vilsmeier reaction of 6-（cyanoindole） with N,N-（diemthylformamide） and phosphorus oxychloride. The structure of the target compound was confirmed by 1H NMR, IR and elemental analysis. The total yield was 57% and the purity of the final （product） reached 99.4%.
Intermediate 6-cyanoindole was obtained from 4-methylbenzonitrile as a raw material via nitration with the mixed acid, condensation with N,N-dimethylformamide dimethyl acetal and cyclic reaction with Raney nickel-hydrazine. 6-Cyanoindole-3-carboxyaldehyde was synthesized via the Vilsmeier reaction of 6-(cyanoindole) with N,N-(diemthylformamide) and phosphorus oxychloride. The structure of the target compound was confirmed by ^(1)H NMR, IR and elemental analysis. The total yield was 57% and the purity of the final (product) reached 99.4%.
出处
《应用化学》
CAS
CSCD
北大核心
2005年第4期454-456,共3页
Chinese Journal of Applied Chemistry
关键词
氰基吲哚
氰基吲哚甲醛
合成
cyanoindole,cyanoindolecarboxaldehyde,synthesis
