摘要
The optical active fork glycerinol （2,2-dimethyl-1,3-dioxolane- 4-methanol）（1） was synthesized with L-serine（2） as the starting material. L-glyceric acid（3） was synthesized via the nitrosation of （2）. With TsOH as the catalyst and 4A molecular sieve as the dehydration agent, L-2,3-O-isopropylidene-glycerate（5） was （directly） prepared from （3）, 2,2′-dimethoxypropane and methanol without isolating the intermediate. Instead of （LiAlH4）, NaBH4 was used to reduce （5） to the final compound （1）. The total yield of was 47%.
The optical active fork glycerinol (2,2-dimethyl-1,3-dioxolane- 4-methanol)(1) was synthesized with L-serine(2) as the starting material. L-glyceric acid(3) was synthesized via the nitrosation of (2). With TsOH as the catalyst and 4A molecular sieve as the dehydration agent, L-2,3-O-isopropylidene-glycerate(5) was (directly) prepared from (3), 2,2′-dimethoxypropane and methanol without isolating the intermediate. Instead of (LiAlH_4), NaBH_(4) was used to reduce (5) to the final compound (1). The total yield of was 47%.
出处
《应用化学》
CAS
CSCD
北大核心
2005年第4期460-461,共2页
Chinese Journal of Applied Chemistry
