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放疗前给予毛果芸香碱对大鼠颌下腺功能的影响 被引量：3

Effect of pilocarpine before irradiation on function of rat submandibular gland
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摘要 目的:探讨电离辐射前给予毛果芸香碱对大鼠颌下腺有无保护作用. 方法:将18只Winstar鼠随机分为对照组和实验组,后者电离辐射前给予毛果芸香碱,一次性10GyX射线局部照射两组大鼠颌下腺区. 照射后96h,比较两组唾液量,唾液电解质及颌下腺组织学差异. 结果:实验组唾液量,Ca2+均高于对照组,且细胞水肿不明显,单位面积内浆液性细胞计数多于对照组,但K+低于对照组. 结论:电离辐射前给予毛果芸香碱对大鼠颌下腺有保护作用. AIM: To explore the protective effects of pilocarpine which was given before X-ray local irradiation on the morphology and function of rat submandibular gland. METHODS: Winstar rats were divided into test and control groups and the latter was given pilocarpine before a single dose of 10 Gy X-ray local irradiation on the area of rat submandibular gland. Ninety-six hours after the local irradiation, the difference between the two groups were compared in the quantity of saliva, the concentration of sodium, calcium and the morphology after HE staining. RESULTS: The quantity of saliva and the concentration of calcium of the test group were higher than those of the control group and the cell edema was not evident. The quantity of serous cells per area was higher than that of the control group, but the concentration of potassium of the test group was lower. CONCLUSION: The pilocarpine before X-ray local irradiation may have some protective effects on the morphology and function of rat submandibular gland.
作者 李娜 刘芳娥 李杨 丰帆 孙朝阳
机构地区 第四军医大学 第四军医大学基础部基础医学教学实验中心 第四军医大学西京医院放疗科
出处 《第四军医大学学报》 北大核心 2005年第7期633-635,共3页 Journal of the Fourth Military Medical University
关键词 电离辐射 毛果芸香碱 大鼠 唾液腺 X-ray irradiation pilocarpine rat submandibular gland
分类号 R979.1 [医药卫生—药品]
  • 相关文献

参考文献5

  • 1李志民,徐勇忠,孙宏晨.电离辐射对大鼠颌下腺形态及功能的影响[J].口腔医学研究,2002,18(6):378-380. 被引量：2
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二级参考文献14

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共引文献1

同被引文献35

  • 1凌昌全,陈连起,陈喆,黄雪强.四生汤抗放疗毒副反应的临床和实验研究[J].中医杂志,1993,34(12):733-735. 被引量：17
  • 2王瑞平.从清热养阴论治恶性肿瘤放疗所致放射性损伤[J].江苏中医药,2006,27(12):24-25. 被引量：7
  • 3张素芳,王晓翠,陈喆.中医药对恶性肿瘤放疗减毒作用的临床研究现状[J].中西医结合学报,2007,5(4):470-474. 被引量：10
  • 4Grundmann O,Mitchell GC,Limesand KH.Sensitivity of salivary glands to radiation:from animal models to therapies.J Dent Res.2009; 88(10):894-903.
  • 5Sagowski C,Wenzel S,Jenicke L,Bohuslavizki KH.Reducing late toxicity with amifostine in fractionated irradiation of the rat salivary glands.HNO.2002; 50(9):822-828.
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  • 9Antonius W T Konings, Rob P Coppes, Arjan Vissink. On the mechanism of salivary gland radiosensitivity [J]. International Journal of Radiation Oncology Biology Physics, 2005,62 (4) : 1187-1194.
  • 10MF Lavin. ATM and the Mrel 1 complex combine to recognize and signal DNA double-strand breaks [J]. Oncogene, 2007, 26 (56): 7749-7758.

引证文献3

二级引证文献9

第四军医大学学报
2005年 第7期

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