β-环糊精衍生物对α-羟丁酸脱氢酶的抑制作用

Inhibiting Action of β-Cyclodextrin Derivative on α-Hydroxybutyrate Dehydrogenase

采用了双 - (6 -氧 -丁烯二酸单酯 ) - β-环糊精和双 [- 6 -氧 - (3-脱氧柠檬酸酯 ) ]- β-环糊精 2种 β-环糊精衍生物( 和 ) ,作为 α-羟丁酸脱氢酶的抑制剂 .在医学上普遍使用的该酶酶活测定的最佳条件下 ,研究了 2种衍生物的抑制效率 .实验证明了 2种衍生物对 α-羟丁酸脱氢酶有抑制作用 .

In this paper two β-cyclodextrin derivative, bis(6-O-butene diacid ester)- β-cyclodextrin (inhibitor Ⅰ) and bis[6-O-(3-deoxy citric ester)]- β-cyclodextrin(inhibitor Ⅱ) was used as the inhibitor of α-hydroxybutyrate dehydrogenase. In the best condition which was used in medicine to determine the activity of α-hydroxybutyrate dehydrogenase, we had researched the inhibiting action of the two β-cyclodextrin derivative on (-hydroxybutyrate dehydrogenase. It was found that both the inhibitor Ⅰ and Ⅱ had inhibiting action on α-hydroxybutyrate dehydrogenase.