摘要
以廉价的靛红为起始原料,经靛红-3-肟和邻氨基苯甲腈两个中间体合成了他克林,并对其进行衍生化合成。所有新化合物的结构均经1HNMR,IR,MS和元素分析确证。
Tacrine was prepared from the condensation of cyclohexanone with 2-cyanoaniline which was made from the industrial isatin. Some of tacrine derivatives were synthesized. Their structures were confirmed by 1H NMR, IR, MS and elemental analysis.
出处
《合成化学》
CAS
CSCD
2005年第2期160-162,共3页
Chinese Journal of Synthetic Chemistry
关键词
老年痴呆症
他克林
衍生物
合成
Alzheimer's disease
tacrine
derivative
synthesis