取代芳香族化合物对4种水生生物的毒性研究

Studies on toxicology of substituted aromatic compounds to four kinds of aquatic organism.

建立了105种取代芳香族化合物对4种水生生物(发光菌、四膜虫、大型蚤和斑马鱼)的毒性QSAR模型.取代芳香族化合物对生物体的毒性主要是由2个过程引起,化合物首先穿透细胞膜,然后与机体发生反应.讨论了生物种的种间和种内差别,这种差别可能与生物的脂肪含量有关.化合物分成了3类,非极性麻醉型化合物、极性麻醉型化合物和反应型化合物,极性麻醉型化合物比非极性麻醉型化合物毒性要高,反应型化合物毒性最高.

Quantitative structure-activity relationships (QSAR) toxicology models were established for the acute 105 kinds of substituted aromatic compound on 4 kinds of different aquatic organism Vibrio fischeri, Tetrahymena pyriformis, Daphnia magna, and Pimephales promelas. The toxicity of the substituted aromatic compounds was mainly induced by two processes: first, the penetration of these compounds through the cell membrane; then the occurrence of these compound reaction with organism species. The difference between species and the intra-species difference was discussed, and these differences might be related to the lipid content of organisms. These compounds were divided into three kinds: non-polar narcotic, polar narcotic; and reactive. The toxicity of reactive compounds was the highest, while the toxicity of polar narcotic was higher than that of non-polar narcotic.