沙培林治疗恶性胸腔积液疗效观察

Observation of Curative Effect for Treating Malignant Pleural Effusion with Sapylin

目的观察沙培林治疗恶性胸腔积液的疗效。方法75例肺癌所致恶性胸腔积液患者随机分为观察组38例和对照组37例。观察组患者每次胸腔内注入沙培林5KE,对照组患者每次胸腔内注入顺铂60mg,5天1次,共3次。观察随访6～12个月。结果观察组有效率显著优于对照组(P<0.05),观察组6、9、12个月生存率显著高于对照组(P<0.05),且观察组不良反应低于对照组。结论沙培林治疗恶性胸腔积液是一种简便、安全、有效的方法。

Objective To investigate the curative effect of treating malignant pleural effusion with Sapylin.Methods 75 patients with malignant pleural effusion of lung cancer were randomly divided into 38 cases of observation group and 37 cases of contrast group .The observation group received intrapleural adminstration of 5KE Sapylin every 5 days and the contrast group were given injection of 60mg Cisplatin into plerual cavity,1 time in 5 days, three times in all.All cases were followed up for 6 to 12 months.Results The effective rate of observation group was more than that of contrast group(P< 0.05).The survival rate of observation group in 6,9,12 months was higher than that of contrast group respectively(P< 0.05).The side effect of observation group was lower than that of contrast group.Conclusion Treating malignant pleural effusion with sapylin is a simple,safe and effective method.