摘要
应用酶联免疫吸附法(ELISA)测定32例风湿性疾病患者膝关节滑膜液的铜锌超氧化物歧化酶(CuZn-SOD),以OD0.1为界,反应性关节炎(ReA)5例均低于0.1;类风湿关节炎(RA)11例中4例低于0.1,均为急性炎症;骨性关节炎(OA)16例,均高于0.1,以ReA及RA为一组,与OA组之间作统计学(X^2)处理,明显低于OA组,差异非常显著。表明了活性氧是急性风湿性疾病关节内的炎性介质之一。
We used Enzyme Linked Immuno-Sorbent Assay (ELISA) to measure Cu Zn superoxide dismutases (Cu Zn-SOD)of knee synovial fluid in 32 patients with rheumatic diseases. OD0.1 was regarded as border value, lower than that in 5cases of reactive arthritis (ReA) and in 4 of 11 cases of rheumatoid arthritis (RA), higher than that in 16 cases of osteoarthritis(OA), CuZn-SOD contents were lower in ReA+RA group than in OA group with obviously statistical difference.It is suggested that oxy radical is one of the inflammatory mediators in the jointsof patients with acute rheumatic diseases.
关键词
类风湿性关节炎
风湿病
滑膜液
超氧化物歧化酶
arthrfts: rheumatoid
rheumatism
synovial fluid
CuZn superoxide dismutase (CuZn-SOD)
oxy radicals
