摘要
Aim To prepare 8-chloro-adenosine (8-Cl-A)long circulation liposomes with high entrapped efficiency and prolonged action-time of 8-Cl-A in vivo. Methods To prepare 8-Cl-A long circulation liposomes of nanometer size by improved multiple emulsion. The entrapped efficiency, size and size distribution of 8-Cl-A long circulation liposomes were determined, and its pharmacokinetics in rats was evaluated. Results The entrapped efficiency of 8-Cl-A long circulation liposomes was 62.70% and mean diameter of the liposomes was 79.9 nm. The pharmacokinetics studies indicated that 8-Cl-A long circulation liposomes showed higher drug concentration and larger AUC values than that of 8-Cl-A after iv to rats. Conclusion 8-Cl-A long circulation liposomes could prolong the action-time of 8-Cl-A in vivo.
Aim To prepare 8-chloro-adenosine (8-Cl-A)long circulation liposomes with high entrapped efficiency and prolonged action-time of 8-Cl-A in vivo. Methods To prepare 8-Cl-A long circulation liposomes of nanometer size by improved multiple emulsion. The entrapped efficiency, size and size distribution of 8-Cl-A long circulation liposomes were determined, and its pharmacokinetics in rats was evaluated. Results The entrapped efficiency of 8-Cl-A long circulation liposomes was 62.70% and mean diameter of the liposomes was 79.9 nm. The pharmacokinetics studies indicated that 8-Cl-A long circulation liposomes showed higher drug concentration and larger AUC values than that of 8-Cl-A after iv to rats. Conclusion 8-Cl-A long circulation liposomes could prolong the action-time of 8-Cl-A in vivo.
出处
《药学学报》
CAS
CSCD
北大核心
2005年第4期382-384,共3页
Acta Pharmaceutica Sinica
基金
"十五"国家重大科技专项资助项目(2002AA2Z3143)
关键词
8-氯腺苷
长循环脂质体
药代动力学
8-chloro-adenosine
long circulation liposomes
pharmacokinetics
