纳络酮对犬心跳骤停复苏后血流动力学影响的实验研究

Hemodynamic Effects of Naloxone in Post-resuscitation Dog from Cardiac Arrest

目的观察纳络酮(naloxone)对犬心跳骤停复苏后血流动力学的影响。方法体外电击诱发犬室颤(VF),3min后复苏,25只犬随机分为常规治疗组(CPR组)12只,纳络酮组(NLX组)7只,正常对照组(NS组)6只,采用Swan-Ganz漂浮导管监测复苏前和后6h的CO。结果CPR组和NLX组各有6只完成6h的观察,两组间的恢复自主循环时间(ROSC)无差异。CPR组的平均动脉压在复苏后4、6h低于NS组,而NLX组在复苏后2、4、6h高于CPR组,与NS组无差异。复苏成功后0-6hNLX组和CPR组的CO均低于NS组,而NLX组则在复苏后1～6h高于CPR组。结论诱发室颤犬复苏成功后存在着心功能不全,NLX能改善犬心肺复苏后血流动力学状态。

Objective To investigate the hemodynamic effects of naloxone in post-resuscitation dog from cardiac arrest. Methods Ventricular fibrillation (VF) was induced, and cardiac output(CO) was measured in 25 dogs before and 6 hours after successful resuscitation from 3 minutes VF. 25 dogs were randomly divided into control group(n=6), CPR group (n=12) and naloxone(NLX) group (n=7). Results Six dogs finished 6-hour experiment in both CPR and NLX groups, and the others did not finish the whole experiment. The time of restoration of spontaneous circulation was not significantly different between CPR group and NLX group. The mean artery pressure(MAP) of CPR group was lower than that of control group in 4, 6 hours after successful resuscitation. The MAP of NLX group was higher than that of CPR group in 2,4 and 6 hours after successful resuscitation, and no significantly different compared with that of normal group. CO in both CPR and NLX groups was lower than that in control group after successful resuscitation. CO in NLX group was higher than that in CPR group in 1 to 6 hours after resuscitation. Conclusion There is myocardial dysfunction in post-resuscitation dog from cardiac arrest. Naloxone can improve their hemodynamic status.