葛根素对CCl_4所致大鼠急性肝损伤的保护作用

Protective effects of puerarin on CCl_4-induced acute hepatic injury in rats

目的 探讨葛根素对CCl4所致的大鼠急性肝损伤的保护作用。方法 用四氯化碳(CCl4)制备急性肝损伤动物模型,用小剂量、大剂量葛根素(4 0mg/kg、2 0 0mg/kg)干预,测定大鼠血清中AST、ALT含量,肝脏指数,以及血清和肝组织匀浆中的SOD活性、MDA量,并作肝组织病理学检测。结果 葛根素能明显降低大鼠血清AST、ALT的含量(P <0 0 5 ) ,降低肝脏指数(P <0 0 5 ) ,降低大鼠血清和肝组织匀浆中的MDA(P <0 0 5 ) ,升高SOD(P <0 0 5 ) ,能减轻肝组织变性、坏死程度,缓解肝组织的病理改变。结论 葛根素对CCl4所致的大鼠急性肝损伤具有保护作用。

Objective To explore the protective effects of puerarin on CCl 4-induced acute hepatic injury of rats. Methods Acute hepatic injury model was induced by CCl 4. Before and after low-dose (40 mg/kg) or high-dose (200 mg/kg) of puerarin was given, the levels of AST, ALT in serum, and liver index, and SOD activity, MDA content in serum and liver tissue were measured. Liver pathological changes were also observed. Results Puerarin reduced the serum levels of AST, ALT obviously (P<0.05), and the liver index (P<0.05), and MDA content (P<0.05) and promoted the activity of SOD (P<0.05). Degeneration and necrosis of liver tissues were relieved. Conclusion Puerarin has protective effects on CCl 4-induced acute hepatic injury in rats.