丙型肝炎病毒感染至肝硬变进程影响因素的分析

Host factors that influence the progression from chronic hepatitis C virus infection to liver cirrhosis

目的 探讨感染丙型肝炎病毒(HCV)时的年龄及既往发病情况、感染途径、性别等因素对患者向肝硬变发展病程的影响。方法 对12 1例丙型肝炎后肝硬变患者分别按感染HCV时的年龄、既往有无急性肝病史、感染HCV途径、性别分组,对感染HCV至发展为肝硬变所需时间进行分析。结果 感染HCV时的年龄越大,自感染HCV至发展为肝硬变所需时间越短(P <0 0 1) ;既往有急性肝病史的患者自感染HCV至发展为肝硬变所需时间较无急性肝病史患者短(P <0 0 1) ;输血感染HCV的患者自感染HCV至发展为肝硬变所需时间较非输血感染者短(P <0 0 5 ) ;自感染HCV至发展为肝硬变所需时间男性与女性患者比较无显著性差异(P >0 0 5 )。结论 感染HCV至发展为肝硬变所需时间受感染HCV时年龄、既往急性发病史、感染途径等因素的影响,与性别关系不显著。

Objective To assess the influence of host factors on the progression to cirrhosis in patients with chronic hepatitis C virus (HCV) infection. Methods Duration of 121 patients from HCV infection developing to liver cirrhosis was compared according to age at which HCV was infected, having the history of acute hepatopathy or not, infection pathway and sex. Patients with other hepatitis virus infection were excluded. Age, at which HCV was infected, was identified as that at blood transfusion or acute episode in non-transfusion patients. No patients had applied to any drugs. Results It took mean (27.17±6.78) years for the patients of age range 0-20 at which HCV was infected to develop to cirrhosis, while only (10.16±5.84) years for those of age range 41～50. There were significant differences between them (P<0.01). Patients with history of acute hepatopathy and those without needed (11.32±1.21) and (17.40±1.46) years respectively to develop to cirrhosis (P<0.01). The mean time for blood transfusion and non-transfusion patients was (12.80±6.85) and (18.00±12.65) respectively (P<0.05). There was no significant difference between female and male patients in the time of developing cirrhosis (P>0.05). Conclusion Our data show that patients with older age at which HCV was infected, with history of acute hepatopathy or HCV infection through blood transfusion developed into liver cirrhosis in shorter time. Sex was not found to have significant influence on the progression to cirrhosis.