熄风静宁冲剂抗大鼠实验性Tourette综合征

Effect of Xifengjingning Granules on experimental tourette syndrome in rats

目的观察熄风静宁冲剂对大鼠Tourette综合征模型和纹状体内多巴胺(DA)和高香草酸(HVA)含量的影响。方法Tourette综合征模型用腹腔注射阿朴吗啡(APO)和局部注射6羟基多巴胺(6OHDA)损毁黑质的方法制造。DA和HVA用HPLC法测定。结果熄风静宁冲剂能对抗APO引起的定型活动和Tourette综合征模型大鼠的旋转行为(P<0.01),且能提高纹状体内HVA含量(P<0.01),作用与氟哌啶醇一致。结论熄风静宁冲剂能减轻Tourette综合征动物模型的症状,其作用机理可能与脑内DA神经有关。

Objective To observe the effects of Xifengjingning Granules (XG) on the model of experimental tourette syndrome (ETS) and the levels of dopamine in corpus striatum and homovanillic acid (HVA). Method The ETS model was established by using ip apomorphine and injecting locally 6-oxydopamine to lesion the black substance. The contents of dopamine and HVA were determined by HPLC.Result XG could inhibit the mold and rotation induced by ip apomorphine of ETS model (P<0.01), and increase the content of HVA in corpus striatum (P<0.01). The effect of XG was as the same as haloperidol. Conclusion XG can relieve the symptoms of ETS model and its mechanism may be related to the brain dopamine nerve.