七味开心颗粒抗抑郁作用实验研究

Anti-depressant-effect of Qiweikaixin Granulae on mice

目的研究七味开心颗粒抗抑郁作用。方法采用小鼠强迫游泳实验、小鼠悬尾实验、拮抗利血平所致的抑郁症状实验,研究七味开心颗粒的抗抑郁作用。结果七味开心颗粒能使小鼠悬尾不动时间和小鼠强迫游泳不动时间显著缩短(P<0.05);显著拮抗利血平所致的体温下降作用和小鼠眼睑下垂及运动不能的作用(P<0.05)。结论七味开心颗粒有抗抑郁的作用。

Objective To study the anti-depressant effect of Qiweikaixin Granulae. Method The mice were given the forced swimming test, tail suspension test and antagonistic test to depressant symptoms induced by reserpine. To observe the anti-depressant effect of Qiweikaixin Granulae. Result Qiweikaixin Granulae significantly shortened fast time in the forced swimming test and tail suspension test in mice, and prevented the depressant symptoms induced by reserpine (P<0.05), such as descent of body temperature, blepharochalasis and acinesia. Conclusion Qiweikaixin Granulae have an anti-depressant effect in mice.