芪红胶囊对病毒性心肌炎小鼠的保护作用

Protective effect of Qihong Capsules on mouse viral myocarditis

目的研究芪红胶囊对病毒性心肌炎动物模型的保护作用。方法以100LD50病毒悬液感染小鼠,造成病毒性心肌炎动物模型;分组为:正常对照组、药效观察组和病毒感染对照组。每天检测动物的体重、进食量和体温变化,共观察21d,最后统计各个分组的死亡率。同样分组后,分别于不同时间进行眼眶取血,测定血清心肌酶含量。结果正常对照组与药效观察组动物死亡率<50%,病毒感染对照组死亡率71.0%,药效观察组与病毒感染对照组之间存在显著性差异(P<0.01);在体重、体温和进食量指标上,病毒感染组与药效观察组之间均存在显著差异(P<0.01)。以上2组的心肌酶含量在第5天时出现明显差别。结论芪红胶囊对病毒性心肌炎动物模型存在明显保护作用。

Objective To investigate the protective effect of Qihong Capsules on mouse viral myocarditis.Method To establish the viral myocarditis model in vivo by infection with 100LD_ 50 coxsackie virus, then divide model into the control group, the experimental group and the infected group. The appetite, weight and body temperature of model were detected daily for 21 days. Then the ratio of death in three groups was counted respectively. The content of serum myocardium enzyme (SME) was determined at different times from the blood taken from mouse orbit in three groups.Results The ratio of death in the control group and the experimental group was below 50%, that in the infected group, 71.0%(P<0.01). There was a significant difference between the infected group and the experimental group in weight, body temperature and appetite (P<0.01), and in the content of SME at the 5th day. Conclusion Qihong Capsules have a protective effect on the mouse model of viral myocarditis.