脑梗死患者自动监测微栓子与粘附分子的相关性及临床意义

Relationship between microembolic signal and adherence factors in cerebral ischemic patients

目的研究脑梗死微栓子与粘附分子的相关性.方法选择76例研究对象,通过TCD自动监测微栓子信号(MES)后分为研究组(MES≥7个/30 min)、对照组(MES介于1～6个/30 min)及空白组(未检出MES),均用双抗体夹心ELISA法测定血清sICAM-1、sVCAM-1、sE-selectine水平.结果研究组sICAM-1、sVCAM-1、sE-selectine水平明显高于对照组、空白组(P＜0.01),且对照组sICAM-1、sVCAM-1、sE-selectine水平高于空白组(P＜0.05).结论粘附分子参与了微栓子的形成过程,两者是发生脑梗死的危险因素,及时给予药物干预对防治脑梗死有积极意义.

Objective To investigate the relationship between microembolic signals (MES) and adherence factors in patients with cerebral ischemia.Methods According to the result of TCD auto monitoring 76 patients were divided into investigating group (MES≥7/ 30 min )、control group (MES between 1 and 6/ 30 min )and blank group (no MES) by auto monitoring MES with TCD.All patients levels of serum sICAM 1、sVCAM 1 and sE selectine were detected by double antibody sandwitch ELISA.Results The levels of serum of sICAM 1、sVCAM 1 and sE selectine in investigating group were significantly higher than those in other groups ( P < 0.01 ).The levels of serum of sICAM 1、sVCAM 1 and sE selectine in control group were higher than those in blank group ( P < 0.05 ).Conclusions It is proved that adherence factors may play an important role in the formation of MES and they are both the dangerous factors of cerebral ischemia.So the prompt medical therapy can protect from cerebral ischemic stroke effectually.