摘要
当手性药物以外消旋体供药用时,其对映体间就可能发生药效学和药代动力学的相互作用。本文综述了手性药物对映体间的药效学和药代动力学相互作用及其对手性药物药效学和药代动力学立体选择性的影响。
Pharmacological interactions between the enantiomers may happen when a chiral drug was used as its racemate. The pharmacodynamic and pharmacokinetic interactions between the enantiomers of chiral drugs, and their effects on the stereoselectivity in pharmacodynamics and pharmacokinetics of chiral drugs were reviewed in this paper.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2005年第1期66-69,共4页
The Chinese Journal of Clinical Pharmacology
关键词
手性药物
药效学
药代动力学
相互作用
立体选择性
chiral drug
pharmacodynamics
pharmacokinetics
drugs interaction
stereoselectivity