ATP敏感性钾通道的阻断剂与开放剂研究进展

Research development on the blockers and openers of ATP-sensitive K^+ channels

ATP敏感性钾通道是高血压、心绞痛、糖尿病及缺血性脑损伤等多种疾病的治疗靶点之一。通过对调节KATP通道药物的选择性、可逆性、作用位点以及相互调节的研究,可以对一些临床用药进行重新评估,并指导开发高选择性的KATP通道阻断剂和开放剂。

ATP-sensitive K + channels are iatreusiologic targets for many diseases such as hypertension, angina pectoris, diabetes mellitus and ischemic brain injury. The investigations on selectivity, reciprocity, effect-site and mutual accommodation of those channels will possibly faciliate the reevaluation of some related drugs and instruct the development of K ATP channel blockers and openers with high selectivity.