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中国汉族人群hGSTA1基因C-69T多态性分析 被引量：2

Genetic polymorphism of human glutathione S-transferase A1 in population of Han nationality in China
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摘要 目的　研究中国汉族人群中人谷胱甘肽S 转移酶(hGSTA1 )C-69T基因多态性的分布。方法1 4 0例血样本来自中国2 5个省份的汉族人口,用聚合酶链反应 限制性片段长度多态性方法检测hGSTA1 69位点的变异。结果　中国汉族人群GSTA1基因 69位点的野生型纯合子(CC)基因型的分布频率为75 .0 %,突变型纯合子(TT)基因型为0 .7%,杂合子(CT)基因型为2 4 .3 %;C及T两种等位基因的频率分别为87.1 %及1 2 .9%。结论中国汉族人群GSTA1基因呈多态性分布。 AIM To investigate the distribution of glutathione S-transferase A1(GSTA1) genetic polymorphism at locus -69 in population of Han nationality in China. METHODS Genomic DNA was extracted from human peripheral blood and the genotypes of GSTA 1 gene polymorphism were analyzed by polymerase chain reaction-restricted fragment length polymorphism(PCR-RFLP) in 140 Chinese Han people. RESULTS(In the population), the proportion of CC, CT and TT genotypes were 75.0%, 24.3% and 0.7%, respectively. Allele frequencies of C and T were detected to be 87.1% and 12.9%, respectively. CONCLUSION The distribution of GSTA1 genes is polymorphism in Chinese Han population and different from those in other racial populations.
作者 平洁 汪晖 黄敏
机构地区 武汉大学医学院药理学系
出处 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2005年第2期108-112,共5页 Chinese Journal of Pharmacology and Toxicology
基金 武汉大学预研基金资助项目 ( 3 0 1 2 70 0 5 0 ) 教育部留学回国人员科研启动基金资助项目 ( 3 0 1 1 5 2 3 3 9)~~
关键词 谷胱甘肽S-转移酶 基因多态性 中国汉族人群 聚合酶链反应-限制性片段长度多态性方法 glutathione S-transferase genetic polymorphism Chinese Han population PCR-RFLP method
分类号 Q987 [生物学—遗传学]
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参考文献14

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同被引文献23

  • 1张永国,亢晋勇.谷胱甘肽硫转移酶的生理功能述评[J].忻州师范学院学报,2006,22(3):125-128. 被引量：9
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  • 5Vanderlelie J, Gude N and Perkins AV. Antioxidant gene expres- sion in preeelamptic placentae: a preliminary investigation[J].Pla- centa,2008,29(6) :519-522.
  • 6Coles BF, Morel F, Rauch C, et al. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression[J]. Pharmacogeneties, 2001,11 (8) : 663- 669.
  • 7Morel F, Rauch C, Coles B,et al.The human glutathione trans- ferase alpha locus., genomie organization of the gene cluster and functional characterization of the genetic polymorphism in the hG- STA1 promoter[J]. Pharmaeogeneties, 2002,12(4) :277-286.
  • 8Cunningham FG, Leveno K J, Bloom SL, et al.Williams Obstetrics [M].23rd ed. New York: McGraw-Hill Professional, 2010:760- 765.
  • 9Hubel CA, Kozlov AV, Kagan VE, et al.Decreased transferrin and increased transferrin saturation in sera of women with preeelamp- sia: implications for oxidative stress[J].Ame J Obste Gyne, 1996, 175 (3 Ptl ) : 692-700.
  • 10Zusterzeel PL, Visser W, Peters WH, et al.Polymorphism in the glutathione S-transferase P1 gene and risk for preeclampsia[J]. Obste Gyne, 2000,96 (1) : 50-54.

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中国药理学与毒理学杂志
2005年 第2期

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