期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

NER与肿瘤耐药 被引量：1

NER and Drug-resistance
下载PDF
导出
摘要 核酸切除修复(nucleotide excision repair,NER)是DNA损伤修复的主要途径,包括ERCC1-6、XPC、 XPA等因子。NER基因缺失与肿瘤易感性有关,NER修复能力与肿瘤耐药性有关。本文就NER的研究进展进行综述。 Nucleotide excision repair (NER) system, including ERCC1-6 factors, XPA, and XPC genes, is the principal way in DNA damage repair. NER gene deficiency has close relationship to tumor susceptibility. Its repair capacity is also related to anti-cancer drug resistance. This paper will review the recent progress on study of NER and drug resistance.
作者 邵翠杰 陈忠平
机构地区 中山大学肿瘤医院神经外科/神经肿瘤科
出处 《中国神经肿瘤杂志》 2005年第1期25-29,共5页 Chinese Journal of Neuro-Oncology
关键词 NER DNA损伤修复 肿瘤易感性 肿瘤耐药性 切除修复 主要途径 基因缺失 修复能力 NER Drug resistance
分类号 R73-361 [医药卫生—肿瘤] R394 [医药卫生—医学遗传学]
  • 相关文献

参考文献10

二级参考文献47

  • 1[1]Safirstein R,Miller P,Guttenplan JB.Uptake and metabolism of cisplatin by rat kidney[J].Kidney Int,1984,25:753-758.
  • 2[2]Poirier MC,Reed E,Litterst CL,et al.Persistence of platinumammine-DNA adducts in Gonads and kidneys of rats and multiple tissues from cancer patients[J].Cancer Research,1992,52:149-153.
  • 3[3]Bergstron P,Johnsson A,Cavallin-Stahl E,et al.Effects of cisplatin and amphotericin B on DNA adduct formation and toxicity in malignant glioma and normal tissues in rat[J].Eur J Cancer,1997,33(1):153-159.
  • 4[4]Houtsmuller AB,Rademakes S,Nigg AL,et al.Action of DNA repair endonuclease ERCC1/XPF in living cells[J].Science,1999,284:958-961.
  • 5[5]Yagi T,Matsumura Y,Sato M,et al.Complete restoration of normal DNA repair characteristics in group F xeroderma pigmentosum cells by over-expression of transfected XPF cDNA[J].Carcinogenesis,1998,19(1):55-60.
  • 6[1]Richard D W. Nucleotide excision repair in mammalian cells. J Boil Chem, 1997,272:23465～23468
  • 7[2]De Vries A, Van Oostrom C, Hofhuis F, Dortant P M, Van Steeg H, Verbeck S. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature,1995,377:169～173
  • 8[4]Ji Shou-ping, You Ying, Wu Ying, Chen Jian-min, Yang Jun and Zhang Yang-pei. Sensitization of ACNU killing effects on HeLa S3 cells by MGMT antisense RNA transfection. Chin Med Sci J,1998,13:14～19
  • 9[5]Qian Yin, Yu Ying-nian, Cheng Xing-ruo, Luo Jian-hong, Xie Hai-yang, Shen Bing-hui. Molecular events after antisense inhibition of hMSH2 in a HeLa cell line. Mutat Res,1998,418:61～71
  • 10[6]O Connor PM, Jackman J, Bae I, Myers T G, Fan S. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Insitute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res, 1999,57:4285～4300

共引文献19

同被引文献4

引证文献1

二级引证文献3

中国神经肿瘤杂志
2005年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部