脑脊液与血清s100β蛋白检测对克-雅氏病诊断价值

Value of s100β protein detection in cerebrospinal fluid and serum in diagnosis of Creutzfeldt-Jakob disease

目的探讨脑脊液和血清中s100β蛋白含量对克雅氏病的诊断意义。方法用固相酶联免疫吸附试验(ELISA)检测13例克雅氏病患者,6例阿尔茨海默病患者和18例无痴呆症状中枢神经系统疾病患者脑脊液和血清中s100β蛋白含量。结果克雅氏病组的脑脊液和血清中s100β蛋白的含量高于阿尔茨海默病组(P<0.01)和无痴呆症状中枢神经系统疾病(P<0.01)。结论脑脊液和血清中s100β蛋白含量检测可以作为克雅氏病诊断指标之一。

Objective To explore the significance of detecting s100β protein in cerebrospinal fluid (CSF) and serum in diagnosis of Creutzfeldt-Jakob disease (CJD). Methods The content of s100β protein in CSF and serum of 13 patients with CJD (CJD group), 6 patients with Alzheimer disease (AD group) and 18 patients with central nervous system diseases without dementia (CNS group) were determined by ELISA. Results The content of s100β protein in CSF and serum of CJD group were significantly higher than those of AD group and CNS group (both P<0.01). Conclusions The content of s100β protein in CSF and serum could be one of diagnostic indexes of CJD.