丙酸钠对肥育猪胆固醇代谢的影响

EFFECTS OF PROPIONATE ON CHOLESTEROL METABOLISM IN FINISHING PIGS

目的:研究丙酸钠对肥育猪胆固醇代谢的影响。方法:将96头体重45kg左右的杜长加肥育猪按饲养试验要求分成4组,每组设三个重复,每个重复8头,分别饲喂添加0、0.5%、1.0%、1.5%丙酸钠的饲粮45d。饲养试验结束后,从每组选出体重相近的8头猪(公母各半)屠宰。结果:(1)添加1.0%和1.5%丙酸钠使血清中总胆固醇、低密度脂蛋白胆固醇显著降低,使高密度脂蛋白/低密度脂蛋白胆固醇的比率显著提高,添加1.5%丙酸钠使血清中极低密度脂蛋白胆固醇显著降低;(2)添加1.0%和1.5%丙酸钠使肝脏中胆固醇和3-羟基-3-甲基戊二酰辅酶A(HMG-CoA)还原酶活性显著降低;(3)添加丙酸钠对肥育猪生长性能、结肠和血清中短链挥发性脂肪酸、粪便中胆固醇和胆汁酸含量均没有显著影响。结论:丙酸钠可以抑制肝脏HMG-CoA还原酶的活性,有效地减少肝脏胆固醇的合成。

Objective: To study the effects of dietary sodium propionate on cholesterol metabolism in finishing pigs. Methods: A total of 96 finishing pigs (Duroc×Landrance×Jia) were randomly alotted to four groups. The groups received the same basal corn-soybean meal diet and sodium propionate was added to the basal diet in the concentrations of 0.5、1.0、1.5 % at the expense of corn, respectively. At the end of the feeding trial, eight pigs from each treatment were slaughtered. Results: (1) Pigs supplemented with 1.0% and 1.5% sodium propionate had significantly lower serum cholesterol and low density lipoprotein cholesterol concentrations and greater ratios of high density lipoprotein/low density lipoprotein cholesterol compared to the control. Pigs supplemented with 1.5% sodium propionate had significantly lower serum very low density lipoprotein cholesterol. (2) Supplementation with 1.0% and 1.5% sodium propionate significantly decreased the cholesterol content in liver and the activity of hepatic 3-hydroxy-3-methylglutary coenzyme A (HMG-CoA) reductase. (3) Supplementation with sodium propionate had no significant effects on growth performance, colonic or serum short-chain acid concentrations, fecal cholesterol or bile acid excretion. Conclusion: Sodium propionate may decrease the activity of hepatic HMG-CoA reductase and suppress the synthesis of cholesterol.