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PTEN和FHIT在口腔鳞癌中的表达及意义 被引量：6

Significance in expression of PTEN and FHIT in oral squamouce cell carcinoma
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摘要 目的:检测抑癌基因PTEN、FHIT在正常口腔黏膜上皮和口腔鳞癌中的表达情况,并探讨其与肿瘤组织学类型的关系。方法:采用SP法免疫组化方法检测6 2例口腔鳞癌中和12例正常口腔黏膜中FHIT、PTEN的蛋白表达。结果:在正常口腔黏膜中PTEN均为强阳性表达(12 / 12 ) ,在口腔鳞癌中2 4 2 % (15 / 6 2 )表现为PTEN蛋白表达的缺乏或减少;而FHIT在正常口腔黏膜中也均为强阳性表达(12 / 12 ) ;在口腔鳞癌中17 7% (11/ 6 2 )表现为FHIT蛋白表达缺乏或减少。结论:PTEN、FHIT在口腔鳞癌的发生过程中起着一定的作用。 Aim: The purpose of this study is to investigate the significance of PTEN and FHIT in normal oral membrane and oral squamouce cell carcinoma (OSCC). The relationship between PTEN, FHIT and pathological characteristics of OSCC was analyzed. Methods: Immunohistochemical staining by SP method was used to detect the expression of PTEN and FHIT in 62 cases of OSCC, and 12 cases of normal oral membrane. Results: PTEN and FHIT were both expressed in all of the normal oral membrane (12/12). In 62 cases of OSCC, PTEN was expressed in 47 cases (47/62), and FHIT was expressed in 51 cases (51/62). Conclusion: Our findings suggest that the tumor suppress gene PTEN and FHIT may both play a role in the pathogenesis of OSCC.
作者 谢思明 沈丽佳 殷操 阮萍 姚希
机构地区 暨南大学医学院口腔医学系 广东省口腔医院
出处 《暨南大学学报（自然科学与医学版）》 CAS CSCD 北大核心 2005年第2期237-241,共5页 Journal of Jinan University(Natural Science & Medicine Edition)
基金 广东省卫生厅资助项目 (A2 0 0 2 136 )
关键词 抑癌基因 PTEN基因 FHIT基因 口腔癌 免疫组化 tumor suppresser gene PTEN gene FHIT gene oral cancer immunohistochemical staining
分类号 R780.2 [医药卫生—口腔医学]
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参考文献10

  • 1周传香,高文信,魏秀峰.口腔鳞癌发展过程中抑癌基因PTEN的蛋白表达及意义[J].口腔医学研究,2003,19(5):365-367. 被引量：6
  • 2李长青,文莲姬,金春顺,崔树勋,房高丽.人喉鳞状细胞癌中PTEN、PCNA的表达及临床意义[J].中国耳鼻咽喉颅底外科杂志,2004,10(1):8-10. 被引量：6
  • 3STECK P A,PERSHOUSE M A,JASSER S A,et al.Identification of a candidate tumour suppressor gene,MMAC1,at chromosome 10q23.3 that is mutated in multiple advanced cancers[J].Nat Genet,1997,15(4): 356-362.
  • 4OHTA M,INOUE H,COTTICELLI M G,et al.The FHIT gene,spanning the chromosome 3p14.2 fragile site and renal carcinoma associated t (3; 8) breakpoint,is abnormal in digestive tract cancers[J].Cell,1996,84(4):587-597.
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二级参考文献33

  • 1OHTA M, INOUE H, COTTICELLI M G, et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma associated t (3; 8) breakpoint, is abnormal in digestive tract cancers [J]. Cell, 1996, 84(4) : 587- 597.
  • 2BARNES, LARRY D, GARRISON, et al. FHIT, a putative tumor suppressor in humans, is a dinocleoside 5', 5" -P1, P3-triphosphate hydrolase[J]. Biochemistry, 1996, 35(36): 11529-11535.
  • 3MURPHY G A, HALLIDAY D, MCLENNAN A G, et al. The Fhit tumor suppressor protein regulates the intracellular concentration of diadenosine triphosphate but not diadenosine tetraphosphate[J]. Cancer Res, 2000, 60(9) :2342-2344.
  • 4PACE H C, GARRISON P N, ROBINSON A K, et al. Genetic, biochemical, and crystallographic characterization of Fhit - substrate complexes as the active signaling form of FHIT[J]. Proc Natl Acad Sci USA, 1998, 95(10) :5484- 5489.
  • 5BRENNER C. FHIT- substrate complexes: a new paradigm in reversible protein phosphorylation phosphorus sulfur and silicon and the related elements[J]. Phosphorus,Sulfur, and Silicon, 1999, 144- 146, 746- 752.
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暨南大学学报（自然科学与医学版）
2005年 第2期

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