兔颅内压升高终术期TCD频谱变化

TCD flow pattern at the last stage of intracranial hypertension in rabbits

目的观察颅内高压终末期兔濒临死亡时的经颅多普勒(TCD)频谱改变过程,对利用TCD协助脑死亡诊断研究作一些探讨。方法采用硬膜外球囊注水法制作急性局灶性颅内高压动物模型,持续监测颅内压及TCD。结果颅内压升高终末期,依次出现3种特征性TCD频谱:舒张期逆向血流、收缩期小三角形血流和无信号。结论3种特征性TCD频谱能够准确地辅助诊断颅高压及其他疾病所致的脑死亡。

Objective To observe the changes of transcranial Doppler flow patterns at the last stage of intracranial hypertension before rabbits' death in order to research the role of transcranial Doppler in the diagnosis of brain death. Methods The animal models with acute intracranial hypertension was established in the means of inserting epidurally the balloon inflated with water. Intracranial pressure and blood flow velocity were measured with transcranial Doppler. Results At the last stage of intracranial hypertension Doppler sonograms showed three characteristic flow patterns in the following sequence: retrograde diastolic flow, small systolic triangular flow, no flow. Conclusion According to three characteristic flow patterns, brain death can be diagnosed reliably.