亮菌粗多糖对小鼠免疫功能的影响

The Effects of Armillariella Polysaccharide on the Immune Function of Mice

通过对血清溶血素值、RES吞噬功能、IL 2的检测、NK细胞活性检测,研究亮菌多糖对小鼠免疫功能的影响.结果表明:亮菌多糖体内给药能激活小鼠网状内皮系统,增强其吞噬功能;能明显拮抗环磷酰胺所致的小鼠溶血素抗体的降低;能提高ConA诱导小鼠体内淋巴细胞产生白介素2的能力;可以增强小鼠脾脏NK细胞的活性.说明亮菌多糖能使小鼠机体免疫力增强.

To investigate the immunomodulatory effect of Armillariella polysaccharide purified from Armillariella tabescens (Scop.ex Fr.)Sing. The effect of Armillariella polysaccharide on mice immunological function was studied by means of determining the production of the hemolysin antibody, the function of macrophage and the production of IL-2. Armillariella polysaccharide had markedly enhanced phagocytic function, and significantly increased the production of the hemolysin antibody on immunosuppression mice caused by cyclophosphamide and the mice's IL-2 production induced by Con A. These results suggest that Armillariella polysaccharide has potent enhancement on immunity.