青年胃癌247例发病与病理特点

An analysis of incidence and pathological characteristics of 247 young patients with gastric carcinoma

目的: 分析青年胃癌的发病特点和病理特征与中老年胃癌的不同特点,为青年胃癌的预防和治疗提供理论依据.方法: 对我院1983 02 /2003 02收治的1839例患者资料进行筛选和研究,对患者性别、发病年龄和病理学类型与分布进行统计分析,并评价遗传因素在胃癌发病中的作用.结果: 青年胃癌以弥漫型多见(40 49% ),病理分型多为低分化腺癌、黏液细胞癌和印戒细胞癌,恶性程度高,女性发病年龄更低,男女性比例接近.具有家族遗传背景或遗传性胃癌患者中青年发病者多于中老年( 39 /189vs69 /1454,P<0 0001; 16 /189vs21 /1454,P<0 0001),男性更易受遗传因素影响.结论: 青年胃癌以高度恶性弥漫型为主,发病呈上升趋势,且与遗传背景有一定的相关性.

AIM: To analyze the incidence and pathological characteristics of gastric cancer in young patients and to explore the possibility of screening and preventing hereditary gastric carcinoma.METHODS: The data of 1839 gastric cancer inpatients between Feb.1983 and Feb.2003 in Xijing Hospital,Fourth Military Medical University were collected.The incidence characteristics included sex,age,pathological type,and hereditary effects were analyzed.RESULTS: The youth with the hereditary background or in hereditary gastric cancer (HGC) kindred had a high possibility of developing the disease(39/189 vs 69/1454,P<0.0001;16/189 vs 21/1454,P<0.0001)and the male had a higher probability.Diffused gastric cancer was common in the young patients (40.49%).By pathological types,the gastric cancer mostly fell in poorly differentiated adenocarcinoma,Krukenberg tumor and signet-ring cell carcinoma,all of which had a bad prognosis.CONCLUSION: The gastric cancers in the young presents an increase tendency with poor differentiation and hereditary factor.