天祝与兰州地区幽门螺杆菌感染流行病学对比研究

Epidemiologic study of Helicobacter pylori infection in Tianzhu and Lanzhou areas

目的比较甘肃天祝县与兰州市两地区居民幽门螺杆菌感染状况,并考察各种相关因素对其感染率的影响。方法采用血清Helicobacterpylori IgG抗体金标渗滤斑点法和14 C 尿素呼气试验检测1780例2 0岁以上居民的H .pylori感染情况。结果天祝县H .pylori感染率76.8% ,显著高于兰州市的5 8.4% (P <0 .0 1)。汉藏两族及男女两性相比,其感染率均无显著差异(P >0 0 5 )。Hp感染与饮水源显著相关,饮用自来水者感染率显著低于饮用池塘/沟渠/河水和井水者(P <0 .0 1。H .pylori感染与人均年收入、碗筷洗刷情况、便后洗手和上消化道症状相关(P <0 .0 5 )。结论天祝和兰州两地区的H .pylori感染率均较高,且前者显著高于后者。H .pylori感染与饮用水源、生活卫生习惯、经济状况和上消化道症状等流行因素显著相关。

Objective To investigate the status of Helicobacter pylori(H.pylori) infection in population of Tianzhu and Lanzhou areas.Methods With 1343 tested subjects in Tianzhu area and 437 controls in Lanzhou area, serologic H.pylori-IgG examination and ~ ~14 C-urea breath test were carried out.Results The H.pylori infective rate in Tianzhu(76.8%) was obviously, higher than that of Lanzhou (58.4%)(P<0.01). Nether nationalities Han and Zang nor sexity(male and female) had significant difference in the Hp infective rate. The residenters drinking water from pond, canal and river had a significantly higher prevalence of H.pylori infection than those drinking tap water (P<0.01). The H.pylori infection was correlated with the overall economic status and the custom of sanitation and symptom of upper alimentary tract. (P<0.05).Conclusion The H.pylori infective rate whether in Tianzhu or in Lanzhou both was high and the former was remarkably higher than the latter. The H.pylori infection was significantly related with such factors as economic status, drinking water sources,sanitation habit and symptom of upper alimentary tract.