摘要
目的:探讨在B超引导下经皮穿刺建立大鼠种植性肝癌模型的可行性及稳定性。材料和方法:52只SD大鼠在B超引导下将浓缩的Walker-256瘤细胞混悬液注入大鼠肝左叶,观察种植的成功率、肿瘤的生长方式、生长速度、B超表现。结果:52只大鼠造模成功51只,成功率98.1%,肿瘤生长方式多为肝内圆形或类圆形单发结节状,B超表现可为高、等高或低回声。个别肿瘤长出肝外或引起癌性腹水。造模3、6、9、12d后肿瘤最大径依次为0.2、0.6、0.9、1.4cm,肿瘤体积依次为0.004±0.001、0.075±0.012、0.288±0.037、1.183±0.215cm3。结论:B超引导下建立大鼠Walker-256种植性肝癌模型具有简单、微创、成功率高等特点,值得推广利用。
Purpose:To explore a new method of establishing implanted hepatic cancer model in rats.Materials and Methods:Concentrated cancerous suspension were injected into the rat liver guided by B-ultra-sound.The success rate of implanted tumors,growth rapidity were evaluated and ultrasonic features were observed.Results:The success rate of implanted tumors was98.1%(51/52),the Maximum di-ameters of tumors3、6、9、12days after implantation were0.2、0.6、0.9、1.4cm respectively and corre-sponding tumor volumes were0.004±0.001、0.075±0.012、0.288±0.037、1.183±215cm 3 .Conclusion:It is a new way to establish implanted liver tumor models and can be used widely.
出处
《中国医学计算机成像杂志》
CSCD
2005年第2期122-124,共3页
Chinese Computed Medical Imaging
基金
国家自然基金资助(30070233)
