摘要
作者利用电子自旋共振法（ＥＳＲ），就１，６－二磷酸果糖（ＦＤＰ）和卡托普利（ＣＰＴ）对离休缺血再灌注家兔心肌组织中氧自由基（ＯＦＲ）水平的影响进行了研究。结果表明，缺血后再灌注初期，离体兔心肌中确有大量的ＯＦＲ形成，ＦＤＰ和ＣＰＴ均有清除ＯＦＲ的作用。从而论证了ＦＤＰ和ＣＰＴ对缺血再灌注心肌的保护作用确与清除ＯＦＲ有关。
Effects of FDP (10mmol/L) and captopril (CPT, 200μmol/L) on oxygen free radicals (OFR) in the ischemic/reperfused rabbit hearts in vitro were studied by means of electron spin resonance spectroscopy (ESR). The ESR spectra obtained in our experiments directly demonstrated large amounts of OFR in the isolated rabbit hearts during early stage of reperfusion. And both FDP and CPT were found to be able to efficiently scavenge OFR generated during reperfusion. These result indicated the protective effect of FDP and CPT on myocardium after reperfusion injury was associated with OFR scavenging.
关键词
心肌缺血
再灌注
心肌
氧
自由基
卡托普利
Myocardium/pathophysiol
Ischemia/reperfusion
Oxygen free radicals/ anal
Rabbits
Electron spin resonance spectroscopy
Fructosediphos-phated/ pharmacol
Captopril/pharmacol
