摘要
目的探讨胸苷酸磷酸化酶(TP)在宫颈上皮内瘤变(CINⅠ、Ⅱ、Ⅲ)及宫颈癌发生、发展中的作用及与预后的关系。方法采用免疫组化S-P法检测TP在慢性宫颈炎、宫颈上皮内瘤变及宫颈癌中的表达。结果TP在宫颈上皮内瘤变中的表达率明显高于慢性宫颈炎;在宫颈癌中的表达率明显高于宫颈上皮内瘤变(P<0.05)及宫颈炎(P<0.05)。在宫颈癌中,TP的表达与临床分期、淋巴结转移及肌层浸润深度有关,与组织学分级无关。结论TP的过度表达与宫颈病变的发生、发展有关,对预测宫颈癌的预后有一定参考价值。
Objective To investigate the role of thymidine phosphorylase (TP) and its prognostic significance in cervical intraepithelial neoplasia (CIN Ⅰ、Ⅱ、Ⅲ)and cervical carcinoma.Methods The expression of TP in chronic cervical inflammation, cervical intraepithelial neoplasia and cervical carcinoma was detected by immunohistochemistry test(S-P method).Results The positive rate of TP in CIN was significantly higher than that of chronic cervical inflammation (P< 0.05), and was also higher in cervical carcinoma than that of in CIN(P< 0.05).The expression rate of TP correlated with clinical stage,lymph node metastases and depth of invasion in cervical carcinoma, but not with histological grade. Conclusion The overexpresssion of TP may be associated with the development and oncogenesis of cervical lesion ,and show some prognostic value.
出处
《医药论坛杂志》
2005年第4期10-11,共2页
Journal of Medical Forum
关键词
宫颈上皮内瘤变
宫颈癌
胸苷酸磷酸化酶
Cervical intraepithelial neoplasia(CIN)
Cervical carcinoma
Thymidine phosphorylase (TP)
